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Department of Veterans Affairs
Veterans Health Administration
Office of Quality & Performance


MEDICALLY UNEXPLAINED SYMPTOMS: CHRONIC PAIN AND FATIGUE


Citation   Medically Unexplained Symptoms: Chronic Fatigue and Pain. Washington, DC: VA/DoD Clinical Practice Guideline Working Group, Veterans Health Administration, Department of Veterans Affairs , and Health Affairs, Department of Defense, August 2002. Office of Quality and Performance publication 10Q-CPG/CF&P-01
Completion Date:   July 2001
Release Date:   August 2002
Source(s):   The Medically Unexplained Symptoms: Chronic Pain and Fatigue Guideline was developed by and written by clinical experts from the DoD, VHA, academia, a team of guideline development specialists, and an experienced moderator who facilitated the multidisciplinary work group. The Work Group included rheumatologists, internists, nurses, family practitioners, psychologists, psychiatrists, specialists in infectious disease, epidemiology, immunology, and occupational health, as well as consultants in the field of guideline and algorithm development. Policy makers and civilian practitioners joined this group of experts from the VHA and DoD.
Adaptation:   A systematic and reproducible search of the literature was conducted. It focused on the best available evidence to address each key question, and ensured maximum coverage of studies at the top of the hierarchy of study types: evidence-based guidelines, meta analyses, and systematic reviews (Cochrane, EBM, EPC reports). The search continued using well-known and widely available databases that were appropriate for the clinical subject.

Limits on language (English), time (1997 through June 2000) and type of research (Randomized Controlled Trials (RCT)) were applied. The search included Medline and additional specialty databases, depending on the topic.

The search strategy did not cast a wide net. Once definitive clinical studies that provided valid relevant answers to the question were identified, the search stopped. It was extended to studies/reports of lower quality (observational studies) only if there were no high quality studies.
Guideline Status:   This is the current release of the guideline. An update is targeted for 2003.
Developer(s):   Veterans Health Administration (VHA), Department of Veterans Affairs (VA) - Federal Government Agency [U.S.] Department of Defense (DoD) - Federal Government Agency [U.S.]
Funding Source:   United States Government
Committee:   Medically Unexplained Symptoms: Chronic Pain and Fatigue Work Group
Group Composition:   List of Contributors
Disease Condition:   Medically Unexplained Symptoms: Chronic Pain and Fatigue
Category:   Assessment; Diagnosis; Treatment: Non Pharmacologic & Pharmacologic; Treatment of Co-Morbid Conditions; Follow Up.
Intended Users:   Designed for use by primary care providers. The guideline can also be used to coordinate, and standardize care and as teaching tools for students and house staff.
Target Population:   Persons eligible for care in the VA or DoD healthcare delivery system.
VHA Contact Person(s):  

VHA :
Mark Brown, PhD
Director, Environmental Agents Service
Department of Veterans Affairs
810 Vermont Avenue, NW
Washington, DC 20420
Ph: (202) 273-8579
Fax: (202) 273-9080
E-mail:
mbrown1@mail.va.gov

DoD:
Charles C. Engel, Jr., MD, LTC, MC, USA
Chief, Deployment Health Clinical Center
Walter Reed Army Medical Center
Building 2, Ward 64, Room 6441
6700 Georgia Avenue, NW
Washington, DC 20307
Ph: (202) 782-8064
Fax: (202) 782-3539
E-mail:
cengel@usuhs.mil
charles.engel@amedd.army.mil

GOALS/OBJECTIVES
  • To promote efficient and effective assessment of patient's complaints.
  • To identify the critical decision points in management of patients with medically unexplained symptoms: chronic pain and fatigue
  • To allow flexibility so that local policies or procedures, such as those regarding referrals to or consultation with specialists
  • To improve local management of patients with chronic unexplained illness and thereby improve patient outcomes
INTERVENTIONS AND PRACTICES

The guidelines are meant to assist clinicians in primary care settings in all aspects of patient care related to medically unexplained symptoms: chronic pain and fatigue.
OUTCOMES CONSIDERED

Goals for individuals with post-deployment health concerns is to focus care at the primary care level, both to enhance the continuity of care and foster the establishment of ongoing therapeutic relationships.
MAJOR RECOMMENDATIONS

The guideline is presented in an algorithmic format and is intended to provide a systematic approach to the evaluation and management of patients with medically unexplained symptoms: chronic pain and fatigue.

CLINICAL ALGORITHMS

Management of Medically Unexplained Symptoms

TYPE OF EVIDENCE

The development process for the Guideline was evidence-based whenever possible. Evidence-based practice integrates clinical expertise with the best available clinical evidence derived from systematic research. Where evidence is ambiguous or conflicting, or scientific data are lacking, the clinical experience within the multidisciplinary group guided the development of consensus-based recommendations.
DESCRIPTION OF METHODS TO COLLECT EVIDENCE

There are very limited published guidelines for this topic. Several published articles focus on a single episode (symptom) of care or a single situation (e.g., management of low back pain). The guideline was designed to cover a broad spectrum of symptoms, and thereby provides an overview of treatment options, as well as discussion about general clinical approaches to patients with MUS.

This document will complement other existing evidence-based clinical based guidelines (CPGs) that address stress-related conditions such as depression, anxiety, tension headache, and musculoskeletal disorders.

METHODS TO ASSESS THE QUALITY AND STRENGTH OF THE EVIDENCE

The literature was critically analyzed with evidence grading. The rating scale used for this document was based on the evidence rating used by U.S. Preventative Services Task Force Guide to Clinical Preventive Services, Second Edition (U.S. PSTF, 1996): Quality of Evidence Rating Scheme (U.S. PSTF, 1996)

The Grading Scheme Used for the Guideline

Quality of Evidence (QE)
Grade Description
I Evidence is obtained from at least one properly randomized controlled trial.
II-1 Evidence is obtained from well-designed controlled trials without randomization.
II-2 Evidence is obtained from well-designed cohort or case-control analytic studies, preferably from more than one center or research group.
II-3 Evidence is obtained from multiple time series with or without the intervention. Dramatic results in uncontrolled experiments could also be regarded as this type of evidence.
III Opinions of respected authorities are based on clinical experience, descriptive studies in case reports, or reports of expert committees.
 
Strength of Recommendation (SR)
Grade Description
A There is good evidence to support the recommendation that the condition be specifically considered.
B There is fair evidence to support the recommendation that the condition be specifically considered
C There is insufficient evidence to recommend for or against the inclusion of the condition, but a recommendation may be based on other grounds.
D There is fair evidence to support the recommendation that the condition be excluded from consideration
E There is good evidence to support the recommendation that the condition be excluded from consideration

REVIEW METHODS

Peer Review

QUALIFYING STATEMENTS

Clinical practice guidelines, which are increasingly being used in health care, are seen by many as a potential solution to inefficiency and inappropriate variations in care. Guidelines should be evidenced-based as well as based upon explicit criteria to ensure consensus regarding their internal validity. However, it must be remembered that the use of guidelines must always be in the context of a health care provider's clinical judgment in the care of a particular patient. For that reason, the guidelines may be viewed as an educational tool analogous to textbooks and journals, but in a more user-friendly tone.

GUIDELINE AVAILABILITY

Electronic copies available from the Office of Quality and Performance website.

Print copies available from:     
The Office of Quality and Performance (10Q)
Veterans Health Administration, Department of Veterans Affairs
810 Vermont, NW
 Washington, DC 20420
    COPYRIGHT STATEMENT:   No copyright restrictions apply.